aurora kinase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5524	Aurora kinase inhibitor-3	Aurora Kinase Inhibitor III	Aurora Kinase
	Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR.		Aurora Kinase
T9040	Aurora kinase inhibitor-2	IUN-70219,Aurora Kinase Inhibitor II	Aurora Kinase
	Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M).		Aurora Kinase
T1825	Reversine		Aurora Kinase , Adenosine Receptor , Autophagy
	Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).		Aurora Kinase , Adenosine Receptor , Autophagy
T6767	TCS7010	Aurora A Inhibitor I	Apoptosis , Aurora Kinase
	TCS7010 (Aurora A Inhibitor I) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay. It is 1000-fold more selective for Aurora A than Aurora B.		Apoptosis , Aurora Kinase
T6532	Hesperadin		Influenza Virus , Parasite , Aurora Kinase , Autophagy
	Hesperadin(IC50=250 nM) effectively inhibits Aurora B. It potently reduces the activity of AMPK, MAPKAP-K1, MKK1, Lck, CHK1 and PHK, but it could not inhibit MKK1 activity in vivo.		Influenza Virus , Parasite , Aurora Kinase , Autophagy
T21981	Phthalazinone pyrazole		Aurora Kinase
	Phthalazinone pyrazole is potent, selective, and orally bioavailable inhibitor of Aurora-A kinase. Aurora-A is overexpressed in a variety of tumor types and displays oncogenic activity.		Aurora Kinase
T10215	AAPK-25		Apoptosis , PLK , Aurora Kinase
	AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in prometaphase, followed by a surge in apoptosis. AAPK-25 targets Aurora-A/-B/-C with ...		Apoptosis , PLK , Aurora Kinase
T6785	BI-847325		Apoptosis , MEK , Aurora Kinase
	BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.		Apoptosis , MEK , Aurora Kinase
T16359	NU6140		CDK , Aurora Kinase
	NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also e...		CDK , Aurora Kinase
T6315	MLN8054		Casein Kinase , PKA , Src , Aurora Kinase
	MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.		Casein Kinase , PKA , Src , Aurora Kinase
T8866	GW779439X		Apoptosis , Antibacterial , CDK , Aurora Kinase
	GW779439X is an inhibitor of CDK.		Apoptosis , Antibacterial , CDK , Aurora Kinase
T6126	JNJ-7706621	JNJ 7706621	Apoptosis , CDK , Aurora Kinase
	JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.		Apoptosis , CDK , Aurora Kinase
T2611	CCT 137690	CCT137690	Apoptosis , Aurora Kinase
	CCT 137690 is a highly specific and oral-available aurora kinase inhibitor, for aurora A(IC50=15 nM ), B(IC50=25 nM) and C(IC50=19 nM).		Apoptosis , Aurora Kinase
T2709	TAK-901	TAK901	JAK , CDK , Src , Aurora Kinase
	TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among others.		JAK , CDK , Src , Aurora Kinase
T2471	MK-8745		Apoptosis , Aurora Kinase
	MK-8745 is a potent and selective Aurora A inhibitor.		Apoptosis , Aurora Kinase
T6077	ZM-447439		Apoptosis , MEK , Src , Aurora Kinase
	ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect aga...		Apoptosis , MEK , Src , Aurora Kinase
T63773	Aurora kinase inhibitor-8
	Aurora kinase inhibitor-8 is a highly selective inhibitor of Aurora kinase.
T62789	Aurora kinase inhibitor-9
	Aurora kinase inhibitor-9 (compound 9d) is a potent AURKA/B bipolar kinase inhibitor, acting on Aurora A (IC50: 0.093 μM), Aurora B (IC50: 0.09 μM). broad-spectrum anti-proliferative activity.
T72522	Aurora kinase-IN-1
	Aurora kinase-IN-1, a potent aurora kinase inhibitor, modulates cell cycle progression and induces apoptosis by upregulating G1 cell cycle inhibitory proteins (including p21 and p27), elevating G1 progressive cyclin D1, ...
T1886	TAK-632		Raf , FGFR , PDGFR , Aurora Kinase
	TAK-632 is a potent pan-Raf inhibitor.		Raf , FGFR , PDGFR , Aurora Kinase